Biological insight, high-throughput datasets and the nature of neuro-degenerative disorders.

Authors: Valente AX, Oliveira PJ, Khaiboullina SF, Palotás A, Rizvanov AA. Link: Publication: Curr Drug Metab. 2013 Sep;14(7):814-8. Life sciences are experiencing a historical shift towards a quantitative, data-rich regime. This transition has been associated with the advent of bio-informatics: mathematicians, physicists, computer scientists and statisticians are now commonplace in the field, working on [...]

By | May 20th, 2016|Publications|0 Comments

Human dendritic cells transfected with a human papilloma virus-18 construct display decreased mobility and upregulated cytokine production.

Authors: Khaiboullina SF, Morzunov SP, Hall MR, De Meirleir KL, Rizvanov AA, Lombardi VC. Link: Publication: Int J Oncol. 2013 Nov;43(5):1701-9. doi: 10.3892/ijo.2013.2074. Epub 2013 Aug 21. The marked depletion of dendritic cells (DCs) in skin cancers, as well as preneoplastic and neoplastic cervical epithelium, suggests a central role for DCs in productive human [...]

By | May 20th, 2016|Publications|0 Comments

Andes-virus-induced cytokine storm is partially suppressed by ribavirin.

Authors: Khaiboullina SF, Rizvanov AA, Lombardi VC, Morzunov SP, Reis HJ, Palotás A, St Jeor S. Link: Publication: Antivir Ther. 2013;18(4):575-84. doi: 10.3851/IMP2524. Epub 2013 Jan 8. BACKGROUND: Microbe-induced over-activation of cytokines, especially tumour necrosis factor (TNF)-α, is key to the pathogenesis of hantavirus infection leading to severe inflammation with high mortality rate. Although [...]

By | May 20th, 2016|Publications|0 Comments

Screening Models of Anticancer Drugs

Authors: Natalia L. Blatt, Rimma N. Mingaleeva, Svetlana F. Khaiboullina, Alexander Kotlyar, Vincent C. Lombardi, Albert A. Rizvanov* Link: Publication: Life Science Journal 2013;10(4) Abstract: Animal models have been indispensable when conducting research to further the understanding of cancer biology and when developing anticancer drugs. This article presents an overview of the most commonly [...]

By | May 20th, 2016|Publications|0 Comments

Application of Cell and Tissue Culture Systems for Anticancer Drug Screening

Authors:1Natalia L. Blatt, 1Rimma N. Mingaleeva, 2Svetlana F. Khaiboullina, 2Vincent C. Lombardi and 1Albert A. Rizvanov Link: Publication: WASJ Abstract: A primary reason why potential anticancer drugs fail in clinical trials is the limitations of existing in vitro screening systems. The purpose of in vitro testing is to aid in the selection of efficacious [...]

By | May 20th, 2016|Publications|0 Comments

Plasmacytoid dendritic cells in the duodenum of individuals diagnosed with myalgic encephalomyelitis are uniquely immunoreactive to antibodies to human endogenous retroviral proteins.

Authors: De Meirleir KL, Khaiboullina SF, Frémont M, Hulstaert J, Rizvanov AA, Palotás A, Lombardi VC Link: Publication: In Vivo. 2013 Mar-Apr;27(2):177-87. Myalgic encephalomyelitis (ME) is a debilitating illness of unknown etiology characterized by neurocognitive dysfunction, inflammation, immune abnormalities and gastrointestinal distress. An increasing body of evidence suggests that disruptions in the gut may [...]

By | May 12th, 2016|Publications|0 Comments